Voltage Imaging

Voltage imaging is a technique used to visualize and measure changes in membrane potential across cells and tissues. It provides insights into biological systems' electrical activity, essential for understanding neuronal communication, cardiac function, and cellular signaling.

The method typically employs voltage-sensitive dyes or genetically encoded voltage indicators (GEVIs). These indicators fluoresce in response to changes in membrane potential, allowing researchers to monitor and quantify voltage changes over time with high spatial and temporal resolution. Advanced imaging technologies like two-photon microscopy enhance depth and minimize phototoxicity, crucial for studying complex tissues.

Voltage imaging finds applications in neuroscience, cardiology, and pharmacology, aiding research on epilepsy, arrhythmias, and ion channel disorders. By revealing cellular electrical behaviors, voltage imaging contributes to the development of new therapies targeting ion channels and membrane dynamics, advancing our understanding of both normal physiology and disease mechanisms.